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An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry
Author(s) -
Doherty Bernadette,
Rodriguez Virginia,
Leslie Julian C.,
McClean Stephen,
Smyth W. Franklin
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3060
Subject(s) - chemistry , chromatography , tandem mass spectrometry , mass spectrometry , collision induced dissociation , electrospray , triple quadrupole mass spectrometer , liquid chromatography–mass spectrometry , electrospray ionization , ion trap , selected reaction monitoring
A tandem mass spectrometric investigation of the collision‐induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time‐of‐flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information. Copyright © 2007 John Wiley & Sons, Ltd.