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A metabonomic study of strain‐ and age‐related differences in the Zucker rat
Author(s) -
Granger Jennifer H.,
Williams Rebecca,
Lenz Eva M.,
Plumb Robert S.,
Stumpf Chris L.,
Wilson Ian D.
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3059
Subject(s) - chemistry , strain (injury) , food science , medicine
Ultra‐performance liquid chromatography (UPLC) coupled to orthogonal acceleration time‐of‐flight mass spectrometry (oa‐TOFMS) in positive electrospray ionization mode was used to obtain metabolite profiles for urine obtained from three strains of Zucker rat. These were the Zucker lean, the Zucker (fa/fa) obese and the Zucker lean/(fa) cross. Clear age‐ and strain‐related differences were noted with the leptin‐deficient (fa/fa) obese animal showing significant differences from both the other Zucker rat strains with respect to metabolite profiles. Copyright © 2007 John Wiley & Sons, Ltd.