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The rapid characterisation of poly(ethylene glycol) oligomers using desorption electrospray ionisation tandem mass spectrometry combined with novel product ion peak assignment software
Author(s) -
Williams Jonathan P.,
Hilton Gillian R.,
Thalassinos Konstantinos,
Jackson Anthony T.,
Scrivens James H.
Publication year - 2007
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.3008
Subject(s) - chemistry , ethylene glycol , mass spectrometry , electrospray , electrospray ionization , tandem mass spectrometry , collision induced dissociation , fragmentation (computing) , peg ratio , analytical chemistry (journal) , desorption , mass spectrum , chromatography , organic chemistry , adsorption , computer science , economics , operating system , finance
A rapid method for the characterisation of polyglycol esters and ethers is described which uses accurate mass desorption electrospray ionisation (DESI) quadrupole time‐of‐flight mass spectrometry (Q‐ToFMS). The results are combined with newly developed software which aids the interpretation of product ions produced using collision‐induced dissociation (CID) of selected precursor ions. The poly(ethylene glycol) (PEG) samples analysed were PEG dibenzoate, PEG monooleate, PEG butyl ether, PEG bis(2‐ethyl hexanoate) and PEG diacrylate. Lithium metal was used for cationisation of the PEG oligomers since it yielded the most useful structural information compared with other group I metals. The full scan mass spectra and product ion mass spectra were all obtained in <5 s. Interpretation of the MS/MS product ion spectra, using the product ion interpretation software which incorporates previously developed fragmentation rules, was carried out in <1 s. Copyright © 2007 John Wiley & Sons, Ltd.