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2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix‐assisted laser desorption/ionisation
Author(s) -
Langley G. John,
Herniman Julie M.,
Townell Marc S.
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2827
Subject(s) - chemistry , matrix (chemical analysis) , ionization , desorption , pencil (optics) , molecule , laser , calibration , analytical chemistry (journal) , chromatography , optics , organic chemistry , ion , adsorption , statistics , physics , mathematics
The effective use of pencil as a matrix for matrix‐assisted laser desorption/ionisation (MALDI) for the study of actinides has previously been demonstrated (Black et al., Rapid Commun. Mass Spectrom. 2006; 20: 1053). Here, the scope of the types of molecules amenable to analysis by this method has been extended, establishing that ∼90% of a library containing 50 diverse small molecules can be successfully analysed by this technique. Further, the role played by the bulk materials present in the different pencil leads has been investigated and a simple one‐step deposition of matrix and calibration materials has been achieved through the fabrication of different calibration pencils (Cali‐Pens). Copyright © 2006 John Wiley & Sons, Ltd.