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Description of response and charge‐state distribution of poly(ether glycol)s in electrospray
Author(s) -
Kéki Sándor
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2734
Subject(s) - chemistry , ethylene glycol , electrolyte , electrospray , analytical chemistry (journal) , ion , peg ratio , charge density , ether , adduct , polymer , chromatography , organic chemistry , physics , electrode , finance , quantum mechanics , economics
The responses and charge‐state distributions of poly(ethylene glycol) (PEG) and poly(propylene glycol) (PPG) (M n = 400–1000 g/mol) at constant electrolyte concentrations (NaCl, 10 −3 mol/L) in electrospray were studied as a function of the analyte concentration in the concentration range of 10 −2 to 10 −7 mol/L. Single charging occurred in the case of PEG and PPG with M n = 400 g/mol. It was observed that the response changed nearly linearly with the concentration of the polymer in the low concentration region but above a certain concentration the response leveled off. Saturation of the response at higher concentrations of PEG and PPG of M n = 1000 g/mol, where double and triple charging occurred, was also observed. Based on the equilibrium partitioning theory a model was developed to account for the response curves and charge‐state distributions of singly, doubly and triply charged adduct ions generated from solutions of PEG and PPG. The experimental and the theoretical response curves and charge‐state distributions calculated with the model are in fairly good agreement. Copyright © 2006 John Wiley & Sons, Ltd.