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Coaxial multi‐electrode cell (‘O‐trap’) for high‐sensitivity detection at a multiple frequency in Fourier transform ion cyclotron resonance mass spectrometry: main design and modeling results
Author(s) -
Misharin Alexander S.,
Zubarev Roman A.
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2724
Subject(s) - fourier transform ion cyclotron resonance , ion cyclotron resonance , coaxial , chemistry , ion trap , cyclotron , ion , mass spectrometry , analytical chemistry (journal) , atomic physics , sensitivity (control systems) , electrode , quadrupole ion trap , excitation , physics , electronic engineering , electrical engineering , chromatography , organic chemistry , quantum mechanics , engineering
Abstract Separation of the functions of ion excitation and detection between different cell compartments allows for implementation of excitation and detection techniques unattainable in a single compartment of the conventional ion cyclotron resonance (ICR) cell. In particular, multi‐electrode detection at a multiple of the main cyclotron frequency can be utilized without the loss of sensitivity and other negative effects. The new O‐trap designed exclusively for ion detection adds an additional, internal coaxial cylinder around which ions with excited cyclotron orbits rotate. Comparison of simulated performance characteristics of the new O‐trap with those of the same‐size conventional cylindrical cell shows that the O‐trap can provide higher sensitivity and ion capacity. Multiplexing of the O‐traps can further increase the analysis speed. Future efforts will be aimed at building and testing experimentally the coaxial O‐trap, including optimization of the method of ion transfer between the compartments of the cell. Copyright © 2006 John Wiley & Sons, Ltd.