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Selectivity of electrospray response in small polymer analysis by mass spectrometry
Author(s) -
Mohamed Salimo,
Charles Laurence
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2713
Subject(s) - chemistry , electrospray mass spectrometry , mass spectrometry , electrospray , chromatography , selectivity , organic chemistry , catalysis
The selectivity of electrospray was explored for a small poly(ethylene)glycol by comparing the oligomer response obtained from direct polymer introduction in flow injection analysis with the signal recorded in high‐performance liquid chromatography/mass spectrometry (HPLC/MS). When the oligomer mixture was ionized, a suppression effect was measured for all but the more hydrophobic congeners for which the response was enhanced. This result would reflect the influence of electrospray droplet chemical composition on the equilibrium partitioning coefficient in Enke's model. On average, the electrospray selectivity observed for the studied poly(ethylene)glycol did not affect the molecular weight distribution parameters as response for the most concentrated oligomers was suppressed to the same extent while over‐expressed largest congeners had a low contribution to the total polymer sample. Copyright © 2006 John Wiley & Sons, Ltd.