Premium
Desorption electrospray ionisation mass spectrometry and tandem mass spectrometry of low molecular weight synthetic polymers
Author(s) -
Jackson Anthony T.,
Williams Jonathan P.,
Scrivens James H.
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2660
Subject(s) - chemistry , mass spectrometry , electrospray , polymer , polypropylene glycol , mass spectrum , desorption , tandem mass spectrometry , chromatography , ethylene glycol , electrospray ionization , analytical chemistry (journal) , organic chemistry , adsorption , polyethylene glycol
A range of low molecular weight synthetic polymers has been characterised by means of desorption electrospray ionisation (DESI) combined with both mass spectrometry (MS) and tandem mass spectrometry (MS/MS). Accurate mass experiments were used to aid the structural determination of some of the oligomeric materials. The polymers analysed were poly(ethylene glycol) (PEG), polypropylene glycol (PPG), poly(methyl methacrylate) (PMMA) and poly( α ‐methyl styrene). An application of the technique for characterisation of a polymer used as part of an active ingredient in a pharmaceutical tablet is described. The mass spectra and tandem mass spectra of all of the polymers were obtained in seconds, indicating the sensitivity of the technique. Copyright © 2006 John Wiley & Sons, Ltd.