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Product ion mass spectra of amphetamine‐type substances, designer analogues, and ketamine using ultra‐performance liquid chromatography/tandem mass spectrometry
Author(s) -
Apollonio Luigino G.,
Whittall Ian R.,
Pianca Dennis J.,
Kyd Jennelle M.,
Maher William A.
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2589
Subject(s) - chemistry , chromatography , mass spectrometry , designer drug , tandem mass spectrometry , high performance liquid chromatography , liquid chromatography–mass spectrometry , drugs of abuse , selected reaction monitoring , analytical chemistry (journal) , drug , pharmacology , medicine
This paper describes the application of ultra‐performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) technology to separate and identify amphetamine‐type substances (amphetamine, methamphetamine), common and novel designer analogues (MDA, MDMA, PMA, 4‐MTA, MBDB), and ketamine using Acquity UPLC/Micromass Quattro Micro API mass spectrometer instrumentation (Waters Corporation, USA). From injection of drug reference standards, it was demonstrated that these compounds can be identified by product ion mass spectra in less than 4 min total analysis time, indicating that the technological advancements associated with UPLC/MS/MS allow it to serve as a powerful analytical tool for high‐throughput testing. In addition to demonstrating the separation and response of these drug compounds under the stated UPLC/MS/MS conditions, we believe the acquired product ion spectra will be a beneficial reference to laboratories interested in incorporating the use of this technology in the routine analysis of drugs of abuse. Copyright © 2006 John Wiley & Sons, Ltd.