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Liquid chromatography/electrospray ionization tandem mass spectrometry analysis of octahydro‐1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocine (HMX)
Author(s) -
Pan Xiaoping,
Zhang Baohong,
Tian Kang,
Jones Lindsey E.,
Liu Jun,
Anderson Todd A.,
Wang JiaSheng,
Cobb George P.
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2576
Subject(s) - chemistry , electrospray ionization , extractive electrospray ionization , mass spectrometry , chromatography , direct electron ionization liquid chromatography–mass spectrometry interface , detection limit , acetic acid , analytical chemistry (journal) , ionization , tandem mass spectrometry , electrospray , dissociation (chemistry) , chemical ionization , sample preparation in mass spectrometry , ion , organic chemistry
A quantitative liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS) method was developed for the analysis of the explosive, octahydro‐1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocine (HMX). In negative ionization mode, HMX forms an acetate adduct ion [M + CH 3 COO] − , m/z 355, in the presence of a small amount of acetic acid in the mobile phase. The ESI collision‐induced dissociation (CID) spectrum of m/z 355 was acquired and the transitions m/z 355 → 147 and m/z 355 → 174 were chosen for the determination of HMX in samples. Using this quantification technique, the method detection limit was 1.57 µg/L and good linearity was achieved in the range 5–500 µg/L. This method will help to unambiguously analyze environmentally relevant concentrations of HMX. Copyright © 2006 John Wiley & Sons, Ltd.