Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry | Zendy

Vivekanandan Kannan | Zendy; Swamy Madugundu Guru | Zendy; Prasad Sudhanand | Zendy; Mukherjee Rama | Zendy; Burman Anand C. | Zendy

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Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry

Author(s) -

Vivekanandan Kannan,

Swamy Madugundu Guru,

Prasad Sudhanand,

Mukherjee Rama,

Burman Anand C.

Publication year - 2006

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.2500

Subject(s) - chemistry , tandem mass spectrometry , adduct , alkali metal , ingredient , electrospray , electrospray mass spectrometry , mass spectrometry , electrospray ionization , chromatography , stereochemistry , organic chemistry , food science

A strategy is developed for the identification of isocephalomannine in the presence of alkali metal ion adducts and other cephalomannine isomers in a paclitaxel active pharmaceutical ingredient. Intact molecular ion analyses and a sub‐structural study have been performed for the differentiation of isocephalomannine (2‐debenzoylpaclitaxel‐2‐pentenoate) from cephalomannine and 7‐epi‐cephalomannine. A comparative study of the cephalomannine isomers was carried out using molecular ions (MS) and fragmentation patterns (MS/MS) for sub‐structural analysis. An attempt has been made to identify isocephalomannine in Cremophor® EL formulations. Copyright © 2006 John Wiley & Sons, Ltd.

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