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The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin
Author(s) -
Williams Jonathan P.,
Patel Vibhuti J.,
Holland Richard,
Scrivens James H.
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2470
Subject(s) - chemistry , dart ion source , chromatography , desorption electrospray ionization , sample preparation , mass spectrometry , electrospray , analytical chemistry (journal) , atmospheric pressure chemical ionization , ionization , ambient ionization , electrospray ionization , desorption , chemical ionization , organic chemistry , electron ionization , ion , adsorption
Abstract Three ionisation techniques that require no sample preparation or extraction prior to mass analysis have been used for the rapid analysis of pharmaceutical tablets and ointments. These methods were (i) the novel direct analysis in real time (DART), (ii) desorption electrospray ionisation (DESI), and (iii) desorption atmospheric pressure chemical ionisation (DAPCI). The performance of the three techniques was investigated for a number of common drugs. Significant differences between these approaches were observed. For compounds of moderate to low polarity DAPCI produced more effective ionisation. Accurate DESI and DAPCI tandem mass spectra were obtained and these greatly enhance the selectivity and information content of the experiment. The detection from human skin of the active ingredients from ointments is reported together with the detection of ibuprofen metabolites in human urine. Copyright © 2006 John Wiley & Sons, Ltd.