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Determination of phthalates in milk and milk products by liquid chromatography/tandem mass spectrometry
Author(s) -
Sørensen Lambert K.
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2425
Subject(s) - chemistry , phthalate , chromatography , dibutyl phthalate , liquid chromatography–mass spectrometry , electrospray , mass spectrometry , extraction (chemistry) , detection limit , tandem mass spectrometry , organic chemistry
A liquid chromatographic/tandem mass spectrometric method using pneumatically assisted electrospray ionisation (LC/ESI‐MS/MS) was developed for determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), di‐2‐ethylhexyl phthalate (DEHP), di‐‘isononyl’ phthalate (DINP) and di‐‘isodecyl’ phthalate (DIDP) in milk and milk products including infant formulas. The phthalates were extracted by a mixture of tert ‐butyl methyl ether and hexane from liquid samples. DBP, BBP and DEHP were removed from fats by liquid/liquid extraction into acetonitrile while DINP and DIDP were cleaned up on deactivated silica. The phthalates were detected in positive ion mode after separation on a reversed‐phase C 5 analytical column. Two transition products were monitored for each compound. The detection limits related to the transition products of lowest abundance were in the range 5–9 µg/kg. Copyright © 2006 John Wiley & Sons, Ltd.