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Studies in organic mass spectrometry. Part 27. Electron ionisation induced isomerisation of 3‐aryl‐4(3 H )‐quinazolinones †
Author(s) -
Ceraulo Leopoldo,
Stefano Vita Di,
Ferrugia Mirella,
Ludányi Krisztina,
Segreto Stefania,
Vékey Károly
Publication year - 2001
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.241
Subject(s) - chemistry , dissociation (chemistry) , kinetic energy , mass spectrum , isomerization , aryl , electron ionization , mass spectrometry , ion , hydrogen atom , ionization , collision induced dissociation , bond dissociation energy , medicinal chemistry , photochemistry , analytical chemistry (journal) , organic chemistry , catalysis , chromatography , tandem mass spectrometry , physics , alkyl , quantum mechanics
The comparison between 70 eV EI (electron ionisation) mass spectra, MIKE (mass analysed ion kinetic energy) and CID (collision induced dissociation) MIKE spectra, KER (kinetic energy release) and KERD (kinetic energy release distribution) data for 2‐methyl‐3‐aryl‐4(3 H )‐quinazolinones 1–4, with those of the corresponding 2‐methyl‐4‐aryloxyquinazolines 1′–4′, indicates that aryloxy radical as well as hydrogen or methyl radical losses involve the formation of common intermediates. This suggests the occurrence of migrations of aryl groups from the N‐3 atom to carboxylic oxygen in the molecular ions of 1–4. Copyright © 2001 John Wiley & Sons, Ltd.