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Analysis of curcuminoids by positive and negative electrospray ionization and tandem mass spectrometry
Author(s) -
Jiang Hongliang,
Somogyi Árpád,
Jacobsen Neil E.,
Timmermann Barbara N.,
Gang David R.
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2401
Subject(s) - chemistry , extractive electrospray ionization , electrospray ionization , tandem mass spectrometry , chromatography , mass spectrometry , protein mass spectrometry , selected reaction monitoring , direct electron ionization liquid chromatography–mass spectrometry interface , top down proteomics , electrospray , sample preparation in mass spectrometry , tandem , analytical chemistry (journal) , chemical ionization , ionization , ion , organic chemistry , materials science , composite material
Abstract The curcuminoids are a group of diarylheptanoid molecules that possess important pharmacological activities, particularly acting as anti‐inflammatory agents. The main purpose of this study was to investigate the fragmentation behavior of the three major curcuminoids in ion trap liquid chromatography/tandem mass spectrometry (LC/MS/MS). Both positive and negative mode electrospray ionization in tandem and multidimensional MS n experiments in quadrupole ion trap instruments and high‐resolution and accurate mass MS and sustained off‐resonance irradiation (SORI) MS/MS experiments in a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer were used to elucidate the main fragmentation channels of these compounds. These experiments yielded essentially the same fragmentation results in both ion trap and ICR instruments for all three curcuminoids and for their phenolic monoacetates. Major and diagnostic fragment ions were identified and their origins are proposed. Copyright © 2006 John Wiley & Sons, Ltd.