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A comparison of the electron ionization and electrospray behaviour of some N,N′‐disubstituted hexahydropyrimidines
Author(s) -
Orelli Liliana R.,
García María B.,
Perillo Isabel A.,
Tonidandel Loris,
Traldi Pietro
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2375
Subject(s) - chemistry , electrospray ionization , ionization , ion , electron ionization , electrospray , mass spectrometry , molecule , hydride , analytical chemistry (journal) , chromatography , organic chemistry , hydrogen
The behaviour of some N,N′‐disubstituted hexahydropyrimidines, a class of naturally occurring compounds of biological and biomedical interest, has been studied in both electron ionization (EI) and electrospray ionization (ESI) modes coupled with collisional experiments (ESI‐MS n ). In both techniques, the [M–H] + ions are highly abundant, even if their formation is generated by two different mechanisms, i.e. H . loss from the M + . species in the case of EI and hydride (H − ) abstraction from the molecules in the case of ESI. Furthermore, due to the low, step‐by‐step internal energy deposition typical of collisional experiments performed in an ion trap mass spectrometer, different fragment ions were observed in EI and ESI‐MS n collisions. In both cases, the ions can be related to the original structure and allow us to identify the positions in which the different substituents are present. Copyright © 2006 John Wiley & Sons, Ltd.