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Combined use of gas chromatography and selected ion flow tube mass spectrometry for absolute trace gas quantification
Author(s) -
Kubišta Jiří,
Španěl Patrik,
Dryahina Kseniya,
Workman Clive,
Smith David
Publication year - 2006
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2340
Subject(s) - chemistry , mass spectrometry , chromatography , breath gas analysis , gas chromatography , analytical chemistry (journal) , gas chromatography–mass spectrometry , trace gas , ion , acetone , organic chemistry
The value of the gas chromatography (GC) and selected ion flow tube mass spectrometry (SIFT‐MS) combination for the analysis of trace gases is demonstrated by the quantification of acetone in air samples using the three precursor ions available to SIFT‐MS, viz. H 3 O + , NO + and O 2 + , and by the separation of the isomers 1‐propanol and 2‐propanol, and their analysis using H 3 O + precursor ions. It is shown that the GC/SIFT‐MS combination allows for accurate trace gas quantification obviating the regular, time‐consuming calibrations that are usually required for the more commonly used detectors of GC systems, and the positive identification of isomers in mixtures that is often challenging using SIFT‐MS alone. Thus, the GC/SIFT‐MS combination paves the way to more confident analyses of complex mixtures such as exhaled breath. Copyright © 2006 John Wiley & Sons, Ltd.