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Study of the electrospray ionization mass spectrometry of the proton pump inhibiting drug Omeprazole
Author(s) -
Weidolf Lars,
Castagnoli Neal
Publication year - 2001
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.226
Subject(s) - chemistry , omeprazole , mass spectrometry , protonation , electrospray ionization , electrospray , molecule , ion , chromatography , organic chemistry , pharmacology , medicine
A detailed analysis of the product ion spectrum generated from the protonated molecule under ESI‐MS/MS conditions using a triple quadrupole mass spectrometer is reported for the gastrointestinal proton pump inhibitor Omeprazole. Unambiguous molecular composition data of the fragment ions were obtained with the aid of regioselectively 14 C‐, 34 S‐ and 18 O‐labeled analogs. Attempts have been made to provide rational pathways for the formation of the fragment ions from four protonated omeprazole species. These results will facilitate the characterization of the complex metabolic fate of Omeprazole in humans, which involves the excretion of at least 50 metabolites. Copyright © 2001 John Wiley & Sons, Ltd.