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Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples
Author(s) -
Williams Jonathan P.,
Scrivens James H.
Publication year - 2005
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2251
Subject(s) - chemistry , mass spectrometry , mass spectrum , analytical chemistry (journal) , electrospray , hybrid mass spectrometer , desorption electrospray ionization , sample preparation in mass spectrometry , tandem mass spectrometry , chromatography , quadrupole mass analyzer , protein mass spectrometry , ion , selected reaction monitoring , electrospray ionization , ion source , thermal ionization mass spectrometry , organic chemistry
Desorption electrospray ionisation (DESI) has been successfully combined with a hybrid quadrupole time‐of‐flight mass spectrometer to provide mass spectra and product ion mass spectra of active ingredients formulated in pharmaceutical tablets, gels and ointments. Accurate mass data has been obtained from the DESI mass spectra and of the product ion fragments of selected ions, greatly enhancing the selectivity and information content of the experiment. This accurate mass information only takes seconds to acquire since the DESI technique does not require any sample preparation or extraction prior to mass analysis. Copyright © 2005 John Wiley & Sons, Ltd.