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Two‐dimensional correlation spectroscopy techniques applied to ion trap tandem mass spectrometric analysis: nitroaromatics
Author(s) -
Sigman Michael E.,
Clark C. Douglas
Publication year - 2005
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2247
Subject(s) - chemistry , nitrobenzene , tandem , ion , fragmentation (computing) , collision induced dissociation , tandem mass spectrometry , mass spectrometry , analytical chemistry (journal) , dissociation (chemistry) , ion trap , quadrupole ion trap , spectroscopy , chromatography , organic chemistry , materials science , physics , quantum mechanics , computer science , composite material , operating system , catalysis
The technique of two‐dimensional (2D) correlation spectroscopy is combined with ion trap tandem mass spectrometric (MS/MS) analysis to provide insight into the energetics and behavior of gas‐phase ions. The 2D correlation method is demonstrated by the analysis of the fragment ions produced by the fragmentation of molecular radical cations of nitrobenzene and m ‐nitrotoluene at a series of applied potentials that effect collision‐induced dissociation (CID). The asynchronous correlation intensities show that competitive loss of NO to form [M–NO] + proceeds at a lower CID energy than loss of NO 2 to form [M–NO 2 ] + . The formation of the ion corresponding to [M–NO–CO] + is shown by the method to occur at a lower CID energy than the formation of [M–NO 2 ] + , but at a higher CID energy than [M–NO] + for both nitrobenzene and m ‐nitrotoluene. Copyright © 2005 John Wiley & Sons, Ltd.