The use of particle beam mass spectrometry for the measurement of impurities in a nabumetone drug substance, not easily amenable to atmospheric pressure ionisation techniques | Zendy

Wolff JeanClaude | Zendy; Hawtin Philip N. | Zendy; Monté Soraya | Zendy; Balogh Michael | Zendy; Jones Tim | Zendy

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The use of particle beam mass spectrometry for the measurement of impurities in a nabumetone drug substance, not easily amenable to atmospheric pressure ionisation techniques

Author(s) -

Wolff JeanClaude,

Hawtin Philip N.,

Monté Soraya,

Balogh Michael,

Jones Tim

Publication year - 2001

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.214

Subject(s) - chemistry , nabumetone , mass spectrometry , impurity , atmospheric pressure , chromatography , analytical chemistry (journal) , ionization , organic chemistry , medicine , ion , oceanography , nonsteroidal , pharmacology , geology

Liquid chromatography/particle beam mass spectrometry (LC/PB‐MS) was used for the structural elucidation of some impurities in nabumetone as this compound poorly ionises by atmospheric pressure ionisation (API) techniques. PB‐MS was optimised for nabumetone and a sensitivity study was carried out. To obtain full scan electron ionisation spectra a minimum of 100 ng of compound on column was needed. By using 20 mg/mL solutions of nabumetone, impurities at levels of about 250 ppm mass fraction relative to nabumetone could be detected. Results were compared with LC/API‐MS and previous GC/MS. Copyright © 2001 John Wiley & Sons, Ltd.

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