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Multi‐residue liquid chromatography/tandem mass spectrometric analysis of beta‐agonists in urine using molecular imprinted polymers
Author(s) -
Van Hoof Nathalie,
Courtheyn Dirk,
Antignac JeanPhilippe,
Van de Wiele Mieke,
Poelmans Sofie,
Noppe Herlinde,
De Brabander Hubert
Publication year - 2005
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2126
Subject(s) - chemistry , chromatography , molecularly imprinted polymer , solid phase extraction , tandem mass spectrometry , molecular imprinting , liquid chromatography–mass spectrometry , mass spectrometry , clean up , ion suppression in liquid chromatography–mass spectrometry , tandem , residue (chemistry) , analytical chemistry (journal) , extraction (chemistry) , selectivity , organic chemistry , materials science , composite material , catalysis
Ion suppression, a matrix effect that affects quantitative mass spectrometry, is one of the main problems encountered in liquid chromatography/tandem mass spectrometry. Two different clean‐up steps for the multi‐residue analysis of beta‐agonists in urine were evaluated with respect to minimisation of ion suppression, namely, a mixed‐phase solid phase extraction (SPE) column, i.e., clean screen Dau (CSD), and a molecular imprinted polymer (MIP) SPE column. Ion suppression experiments revealed that CSD sample clean‐up can lead to false negative results for some beta‐agonists, and that clean‐up using MIP columns is more selective for beta‐agonists than the use of CSD columns. Copyright © 2005 John Wiley & Sons, Ltd.