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Effect of delay time and grid voltage changes on the average molecular mass of polydisperse polymers and polymeric blends determined by delayed extraction matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
Author(s) -
Mineo Placido,
Vitalini Daniele,
Scamporrino Emilio,
Bazzano Sebastiano,
Alicata Rossana
Publication year - 2005
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2123
Subject(s) - chemistry , dispersity , mass spectrometry , analytical chemistry (journal) , polymer , desorption , mass spectrum , time of flight mass spectrometry , molecular mass , matrix (chemical analysis) , polyethylene glycol , extraction (chemistry) , matrix assisted laser desorption electrospray ionization , ionization , ambient ionization , polyethylene , chromatography , matrix assisted laser desorption/ionization , ion , polymer chemistry , chemical ionization , organic chemistry , adsorption , enzyme
The dependence of the calculated average molecular mass of a polyethylene glycol with a large polydispersity on the instrumental parameters adopted in the acquisition of mass spectra using delayed extraction matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (DE MALDI‐TOFMS) was investigated. It has been shown that a combined effect of delay times and potential gradients can act on the ion cloud in the source chamber affecting both mass resolution and average molecular mass value of the analyzed polymeric sample. Also examined was a blend of two different polymers (a PEG and a PMMA commercial sample having a similar average molecular mass), which presents an additional problem concerning the discrimination among the different polymer species as a function of the experimental conditions. In this work, the best instrumental conditions to obtain both good resolution and a correct average molecular mass for the examined polydisperse sample are reported. Copyright © 2005 John Wiley & Sons, Ltd.