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A new interface to couple thin‐layer chromatography with laser desorption/atmospheric pressure chemical ionization mass spectrometry for plate scanning
Author(s) -
Peng Song,
Edler Michael,
Ahlmann Norman,
Hoffmann Thorsten,
Franzke Joachim
Publication year - 2005
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.2120
Subject(s) - chemistry , mass spectrometry , desorption , matrix assisted laser desorption electrospray ionization , desorption electrospray ionization , analytical chemistry (journal) , atmospheric pressure , laser , chromatography , atmospheric pressure laser ionization , ionization , atmospheric pressure chemical ionization , chemical ionization , matrix assisted laser desorption/ionization , photoionization , adsorption , optics , organic chemistry , ion , oceanography , physics , geology
Abstract An interface to allow on‐line qualitative and quantitative full‐plate detection and analysis of compounds separated by thin‐layer chromatography (TLC) is presented. A continuous wave diode laser is employed as a desorption source. Atmospheric pressure chemical ionization mass spectrometry ionizes and subsequently identifies the desorbed sample molecules. Besides direct laser desorption on untreated TLC plates, graphite particles were used as a matrix to couple in the laser power and improve the efficiency of desorption. Copyright © 2005 John Wiley & Sons, Ltd.