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Matrix‐assisted laser desorption/ionization and electrospray ionization mass spectrometric study of 2,3‐dihydro‐1,4‐benzoxazepines
Author(s) -
Kéki Sándor,
Nagy Lajos,
Deák György,
Lévai Albert,
Zsuga Miklós
Publication year - 2005
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1920
Subject(s) - chemistry , adduct , fragmentation (computing) , electrospray ionization , ionization , dissociation (chemistry) , mass spectrometry , electrospray , ion source , desorption , protonation , ion , matrix assisted laser desorption electrospray ionization , analytical chemistry (journal) , molecule , electron ionization , chromatography , organic chemistry , adsorption , computer science , operating system
Fragmentations of the protonated adduct ions [M+H] + of seven 1,4‐benzoxazepine derivatives were studied using ‘post‐source decay’ matrix‐assisted laser desorption/ionization (PSD MALDI) and electrospray nozzle‐skimmer collisionally induced dissociation (ESI‐CID) mass spectrometric methods. It was found that both methods generated mainly product ions arising from the cross‐ring cleavages of the benzoxazepine ring. Similar product ions were generated under MALDI and ESI conditions; however, it was observed that the loss of the alkylene unit from the N‐substituted benzoxazepine, and the loss of a H 2 X molecule (where X = O or S), are more preferred under ESI conditions. Based on the experimental results a mechanism is also proposed for the fragmentation of the oxazepines studied. Copyright © 2005 John Wiley & Sons, Ltd.