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Electron ionization fragmentation mechanisms of different substituted 2,3‐dihydro‐ and 2,3,4,5‐tetrahydro‐1,5‐benzothiazepines
Author(s) -
Ansari Farzana Latif,
Hussain Latif,
Nasir Saima,
Sultana Sajida
Publication year - 2005
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1905
Subject(s) - chemistry , fragmentation (computing) , ionization , electron ionization , computational chemistry , photochemistry , medicinal chemistry , organic chemistry , ion , computer science , operating system
The electron ionization induced fragmentations of ten biologically significant 2,3‐dihydro‐1,5‐benzothiazepines and the corresponding 2,3,4,5‐tetrahydro‐1,5‐benzothiazepines have been studied by low‐ and high‐resolution mass spectrometry. The fragmentations follow a general pattern, the details of which are discussed with respect to the nature and position of the substituent in the aromatic ring. The dihydro‐ and tetrahydro‐1,5‐benzothiazepines both undergo fragmentation through four routes (A–D). However, the most significant fragmentation takes place through route A, leading to the elimination of ring A or ring B of the molecule. The difference between the fragmentation patterns of dihydro‐ and tetrahydro‐1,5‐benzothiazepines appears mainly in route E where a phenylallylhydroxybenzene cation appears in all tetrahydro‐1,5‐benzothiazepines but is not observed in the corresponding dihydro derivatives. Copyright © 2005 John Wiley & Sons, Ltd.