Determination of  N  9 / N  7 ‐isomer ratio of alkyl (guaninyl)acetates by electrospray ionization tandem mass spectrometry | Zendy

Ferenc Györgyi | Zendy; Kele Zoltán | Zendy; Kovács Lajos | Zendy

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Determination of N 9 / N 7 ‐isomer ratio of alkyl (guaninyl)acetates by electrospray ionization tandem mass spectrometry

Author(s) -

Ferenc Györgyi,

Kele Zoltán,

Kovács Lajos

Publication year - 2004

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.1774

Subject(s) - chemistry , electrospray ionization , structural isomer , tandem mass spectrometry , mass spectrometry , alkyl , alkylation , electrospray , tandem , ionization , analytical chemistry (journal) , medicinal chemistry , chromatography , ion , organic chemistry , catalysis , materials science , composite material

N 9 ‐ and N 7 ‐Substituted (guaninyl)acetic esters were studied by electrospray ionization tandem mass spectrometry (ESI‐MS/MS) in order to determine their ratio in alkylation reactions. The loss of ammonia is significantly different for the N 9 ‐ and N 7 ‐alkylated guanine regioisomer pairs. More importantly, the abundance of the [MH–17] + ion is in linear correlation with the N 9 ‐isomer content. Therefore, the ratio of regioisomers can be determined in a mixture containing these compounds. Copyright © 2004 John Wiley & Sons, Ltd.

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