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The analysis of high explosives by liquid chromatography/electrospray ionization mass spectrometry: multiplexed detection of negative ion adducts
Author(s) -
Mathis John A.,
McCord Bruce R.
Publication year - 2004
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1752
Subject(s) - chemistry , adduct , electrospray ionization , explosive material , mass spectrometry , chromatography , extractive electrospray ionization , formate , selectivity , chemical ionization , electrospray , high performance liquid chromatography , ion chromatography , ion , ionization , analytical chemistry (journal) , sample preparation in mass spectrometry , organic chemistry , catalysis
The negative ion electrospray ionization mass spectrometric (ESI‐MS) detection of adducts of high explosives with chloride, formate, acetate, and nitrate was used to demonstrate the gas‐phase interaction of neutral explosives with these anions. The relative intensities of the adduct species were determined to compare the competitive formation of the selected high explosives and anions. The relative stability of the adduct species varies, yielding preferential formation of certain anionic adducts with different high explosives. To exploit this effect, an isocratic high‐performance liquid chromatography (HPLC)/ESI‐MS method was developed and used for the simultaneous analysis of high explosives using two different techniques for the addition of the anionic additives; pre‐ and post‐column. The results show that the pre‐column approach provides similar results with improved selectivity for specific explosives. By detecting characteristic adduct species for each explosive, this method provides a qualitative and quantitative approach for the analysis and identification of high explosives. Copyright © 2004 John Wiley & Sons, Ltd.