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Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals
Author(s) -
Finch Jeffrey W.,
Toerne Kevin A.,
Schram Karl H.,
Denton M. Bonner
Publication year - 2004
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1742
Subject(s) - chemistry , photoionization , mass spectrometry , mass spectrum , derivatization , ultraviolet , chromatography , analytical chemistry (journal) , laser , ion , ionization , organic chemistry , optics , physics
A photoionization hydrogen laser time‐of‐flight mass spectrometer system (H 2 ‐TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H 2 ‐TOFMS showed primarily intact molecular ions (M + . ) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid‐phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents. Copyright © 2004 John Wiley & Sons, Ltd.