Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals | Zendy

Finch Jeffrey W. | Zendy; Toerne Kevin A. | Zendy; Schram Karl H. | Zendy; Denton M. Bonner | Zendy

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Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

Author(s) -

Finch Jeffrey W.,

Toerne Kevin A.,

Schram Karl H.,

Denton M. Bonner

Publication year - 2004

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.1742

Subject(s) - chemistry , photoionization , mass spectrometry , mass spectrum , derivatization , ultraviolet , chromatography , analytical chemistry (journal) , laser , ion , ionization , organic chemistry , optics , physics

A photoionization hydrogen laser time‐of‐flight mass spectrometer system (H 2 ‐TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H 2 ‐TOFMS showed primarily intact molecular ions (M + . ) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid‐phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents. Copyright © 2004 John Wiley & Sons, Ltd.

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