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Synthesis and identification of two potential oxidation degradants of oxymetazoline
Author(s) -
Leader Ian P.,
Halket John,
Finch Paul
Publication year - 2004
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1534
Subject(s) - chemistry , oxymetazoline , chromatography , fragmentation (computing) , mass spectrometry , electrospray , mass spectrum , electrospray ionization , biochemistry , adrenergic receptor , receptor , computer science , operating system
Two potential oxidation degradants of oxymetazoline have been isolated by liquid chromatography and monitored by electrospray single quadrupole mass spectrometry. The structures of the products are shown to be oxymetazoline N ‐oxide and hydroxyamine by multiple‐stage fragmentation ion trap mass spectrometry. The product ion spectra were installed in a library database and the library was used to examine an aged commercial product; one of the degradants was detected, but at a level of less than 0.1% of the parent. Copyright © 2004 John Wiley & Sons, Ltd.