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Post‐source decay matrix‐assisted laser desorption/ionization mass spectrometric study of tetracyclic 2,3‐dihydro‐1,5‐benzothiazepines
Author(s) -
Kéki Sándor,
Nagy Lajos,
Deák György,
Lévai Albert,
Zsuga Miklós
Publication year - 2004
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1476
Subject(s) - chemistry , ionization , desorption , matrix (chemical analysis) , mass spectrometry , analytical chemistry (journal) , chromatography , organic chemistry , ion , adsorption
The fragmentation behavior of six tetracyclic 2,3‐dihydro‐1,5‐benzothiazepine derivatives cationized with protons and silver ions under post‐source decay (PSD) matrix‐assisted laser desorption/ionization (MALDI) conditions is reported. The protonated adduct ions decompose into several structurally important fragment ions, including substituted cyclopropane and benzohydrothiazole cations. Elimination of Ag and H and/or AgH from the silver‐cationized adduct ions of these ([M+Ag] + ) compounds was observed. It was also found that [M+Ag] + produced silver‐depleted fragment ions exclusively. Based on the PSD results a fragmentation pathway is proposed for the [M+H] + and [M+Ag] + precursor ions. Copyright © 2004 John Wiley & Sons, Ltd.