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Gas‐phase ligand loss and ligand substitution reactions of platinum(II) complexes of tridentate nitrogen donor ligands
Author(s) -
Wee Sheena,
O'Hair Richard A. J.,
McFadyen W. David
Publication year - 2004
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1469
Subject(s) - chemistry , ligand (biochemistry) , molecule , substitution reaction , deuterium , medicinal chemistry , stereochemistry , nitrogen , ion , proton , crystallography , organic chemistry , receptor , biochemistry , physics , quantum mechanics
The source of protons associated with the ligand loss channel of HX (n − 1)+ from [Pt II (dien)X] n+ (X = Cl, Br and I for n = 1 and X = NC 5 H 5 for n = 2) in the gas phase was investigated by deuterium‐labelling studies. The results of these studies indicate that these protons originate from both the amino groups and the carbon backbone of the dien ligand. In some instances (e.g. X = Br and I), the protons lost from the carbon backbone can be even more abundant than the protons lost from the amino groups. The gas‐phase substitution reactions of coordinatively saturated [Pt II (L 3 )L a ] 2+ complexes (L 3 = tpy or dien) were also examined using ion‐molecule reactions. The outcome of the ion‐molecule reactions depends on both the ancillary ligand (L 3 ) as well as the leaving group (L a ). [Pt II (tpy)L a ] 2+ complexes undergo substitution reactions, with a faster rate when L a is a good leaving group, while the [Pt II (dien)L a ] 2+ complex undergoes a proton transfer reaction. Copyright © 2004 John Wiley & Sons, Ltd.