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Characterisation of new pyridazinofurocoumarins by electron ionisation and multiple stage tandem mass spectrometry using an ion trap mass spectrometer
Author(s) -
Begala Michela,
GonzálezGómez Jose Carlos,
Podda Gianni,
Santana Lourdes,
Tocco Graziella,
Uriarte Eugenio
Publication year - 2004
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1363
Subject(s) - chemistry , mass spectrometry , selected reaction monitoring , ion trap , hybrid mass spectrometer , tandem mass spectrometry , ion , tandem , top down proteomics , analytical chemistry (journal) , thermal ionization mass spectrometry , electron ionization , ion mobility spectrometry–mass spectrometry , ionization , chromatography , aerospace engineering , engineering , organic chemistry
The inverse electron‐demand Diels‐Alder reaction between furocoumarinones and 3,6‐bis(methoxycarbonyl)‐1,2,4,5‐tetrazine was used to give pyridazinofurocoumarins in good yields. The structural characterisation of the synthesised compounds was achieved by NMR spectroscopy. The mass spectrometric behaviour was studied under electron ionisation conditions via sequential product ion fragmentation experiments (MS n ). This study allowed the evaluation of the role played by the methyl substituent on the benzene ring of pyridazinofurocoumarins in their fragmentation pathways. Copyright © 2004 John Wiley & Sons, Ltd.