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Synthesis and electrospray ionization mass spectra of AZT/d4T boranophosphates
Author(s) -
Lin Changxue,
Fu Hua,
Zhao Yufen
Publication year - 2004
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1324
Subject(s) - chemistry , electrospray ionization , fragmentation (computing) , mass spectrometry , tandem mass spectrometry , phosphinate , mass spectrum , electrospray , collision induced dissociation , chromatography , protein mass spectrometry , extractive electrospray ionization , phosphonate , selected reaction monitoring , sample preparation in mass spectrometry , ion , organic chemistry , fire retardant , computer science , operating system
New anti‐HIV prodrugs, conjugates of AZT and d4T with boranophosphates, were prepared by the H‐phosphonate method. Their structures were determined by negative ion electrospray ionization mass spectrometry (ESI‐MS) in conjunction with tandem mass spectrometry (MS/MS). The fragmentation pathways were investigated, and most of the fragment ions contained the boranophosphate or phosphinate group. Copyright © 2004 John Wiley & Sons, Ltd.