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High‐flow liquid chromatography/mass spectrometry interface using a parallel ion spray
Author(s) -
Hiraoka K.,
Fukasawa H.,
Matsushita F.,
Aizawa K.
Publication year - 1995
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290091406
Subject(s) - chemistry , body orifice , electrospray , analytical chemistry (journal) , capillary action , ion , nebulizer , mass spectrometry , volumetric flow rate , chromatography , corona discharge , mechanics , electrode , materials science , medicine , ecology , physics , organic chemistry , anesthesia , composite material , biology
By positioning the capillary of the ion spray parallel to the ion sampling orifice, several advantages have been found compared to the conventional perpendicular ion spray, e.g., higher sensitivity, stable operation, practically no contamination of the ion sampling orifice, and higher liquid flow rates up to 4 mL/min. This is due to the fact that while the charged fine liquid droplets are deflected towards the ion sampling orifice, the larger liquid droplets with lower charge density are entrained in the nebulizer gas jet and they are carried away outside the ion sampling system. With higher liquid flow rates (e.g. ⩾500 μL/min), the start of corona discharge does not result in a drastic decrease in the signal intensities of ions originating from sample solution. In electrospray experiments, it has also been found that the parallel spray gives better performance than the perpendicular one.