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A Faraday cup detector for high‐mass ions in matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
Author(s) -
Imrie D. C.,
Pentney J. M.,
Cottrell J. S.
Publication year - 1995
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290091314
Subject(s) - mass spectrometry , chemistry , time of flight mass spectrometry , ionization , ion , time of flight , analytical chemistry (journal) , detector , faraday cup , hybrid mass spectrometer , selected reaction monitoring , optics , physics , chromatography , tandem mass spectrometry , ion beam , organic chemistry
A detector has been developed, which collects and amplifies the electric charge of an incoming bunch of ions, for use in matrix‐assisted laser desorption/ionization (MALDI) time‐of‐flight (TOF) mass spectrometry. The detector has a time‐of‐flight resolution of about 50 ns and a noise level of 750 electrons rms. It has been tested in a Finnigan LaserMAT spectrometer with a number of samples which Were expected to give reliable results in MALDI time‐of‐flight mass spectrometry. Clear mass peaks have been observed from samples with masses above 300 kDa.