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A combined magnetic sector–time‐of‐flight mass spectrometer for structural determination studies by tandem mass spectrometry
Author(s) -
Bateman R. H.,
Green M. R.,
Scott G.,
Clayton E.
Publication year - 1995
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290091302
Subject(s) - chemistry , mass spectrometry , ion source , hybrid mass spectrometer , time of flight mass spectrometry , ion , selected reaction monitoring , mass spectrum , analyser , time of flight , analytical chemistry (journal) , ambient ionization , ionization , tandem mass spectrometry , top down proteomics , thermal ionization mass spectrometry , ion beam , electron ionization , chromatography , organic chemistry
A combined magnetic sector–time‐of‐flight instrument has been constructed and used with both continuous (liquid secondary ion mass spectrometry and electrospray ionization) and pulsed (matrix‐assisted laser desorption/ionization) ion sources. The design includes provision for both low‐ and high‐energy gas collision induced decompositions and orthogonal acceleration of the product ions into the time‐of‐flight mass analyser. Tandem mass spectra may be acquired for singly and multiply charged precursor ions and reliable mass measurements are easily obtained. Product‐ion mass spectra are quite reproducible regardless of any instability in the precursor ion beam intensity.