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Ionophores: Potential screening via supercritical‐fluid chromatography combined with mass spectrometry and tandem mass spectrometry
Author(s) -
Ramsey E. D.,
Berry A. J.,
Lawrence S. D.,
Games D. E.,
Startin J. R.
Publication year - 1995
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290090816
Subject(s) - chemistry , chromatography , mass spectrometry , supercritical fluid chromatography , tandem mass spectrometry , supercritical fluid , sample preparation in mass spectrometry , selected reaction monitoring , ionophore , tandem , gas chromatography , organic chemistry , electrospray ionization , composite material , calcium , materials science
A variety of ionophores have been studied by packed column supercritical‐fluid chromatography combined with mass spectrometry. One of the ionophores, lasalocid, provided particularly good multiple‐reaction monitoring signal‐to‐noise responses when analysed by tandem mass spectrometry and this approach shows considerable potential for the analysis of this compound in medicated animal feeds. A capillary supercritical‐fluid chromatograph has been interfaced to an unmodified benchtop quadrupole mass spectrometer and this combination has enabled the molecular weight determination of the sodium salt of an ionophore.