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252 Cf‐plasma desorption mass spectrometry analysis of lipids A obtained by an elimination reaction under mild conditions
Author(s) -
Lebbar Souad,
Karibian Doris,
HaeffnerCavaillon Nicole,
Beyec Yvon Le,
Caroff Martine
Publication year - 1995
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290090812
Subject(s) - chemistry , mass spectrometry , desorption , qualitative analysis , chromatography , mass spectrum , organic chemistry , adsorption , qualitative research , social science , sociology
Abstract Lipids A are the hydrophobic domains of bacterial endotoxic lipopolysaccharides. Since they are responsible for most of the biological activities (both pathogenic and beneficial) of endotoxins, the characterization of their structure is crucial to the understanding of their mode of action. However, the inadequacy of existing methods for preparing certain lipids A has prompted us to devise a new, mild procedure which gives intact products. Use was made of the special features of 252 Cf‐plasma desorption mass spectrometry for forming molecular ions from these species and giving qualitative and quantitative information from the primary mass spectrum.