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Automated liquid chromatography/mass spectrometry for chromatographers
Author(s) -
Pullen Francis S.,
Richards Donald S.
Publication year - 1995
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290090216
Subject(s) - chemistry , mass spectrometry , chromatography , analytical chemistry (journal) , sample (material) , mass spectrum , high performance liquid chromatography
Automated ‘open access’ mass spectrometry with liquid interfaces is now considered routine in our laboratories at Sandwich, UK. Synthetic chemists log samples into a queue on the mass spectrometer and return a short time later to take the mass spectrum and the sample away. The whole process occurs without any intervention by a mass spectroscopist (D. V. Bowen, M. Dalton, G. Perkins, F. Pullen and D. Richards, Rapid Commun. Mass Spectrom. Vol. 8, p. 632 (1994)). Fast response liquid chromatography/mass spectrometry is a further development in ‘open access’ mass spectrometry driven by the needs of chromatographers, for whom it is important that the identity of each component present in a high‐performance liquid chromatographic separation is known. This Communication describes the development of such a system for our laboratories.