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Charge‐remote fragmentation of peptides derivatized with 4‐aminonaphthalenesulphonic acid
Author(s) -
Lindh Ingemar,
Griffiths William J.,
Bergman Tomas,
Sjövall Jan
Publication year - 1994
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290081002
Subject(s) - chemistry , fragmentation (computing) , dissociation (chemistry) , collision induced dissociation , ion , fast atom bombardment , peptide , mass spectrum , mass spectrometry , analytical chemistry (journal) , tandem mass spectrometry , chromatography , organic chemistry , biochemistry , computer science , operating system
A series of small peptides has been studied by negative‐ion fast‐atom bombardment mass spectrometry with collision‐induced dissociation. It has been found that by derivatizing peptides with 4‐aminonaphthalenesulphonic acid in a peptide linkage at the C‐terminus, negative‐ion formation can be enhanced and fragmentation in collision‐induced dissociation reactions controlled. The peptide‐naphthalenesulphonates show charge‐remote fragmentations and the resultant spectra give sequence information.

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