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An automated liquid chromatography/mass spectrometry system coupled on‐line with microdialysis for the in vivo analysis of contrast agents
Author(s) -
Michelsen Peter,
Pettersson Göran,
Games D. E.
Publication year - 1994
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290080705
Subject(s) - chemistry , microdialysis , chromatography , mass spectrometry , sample preparation , high performance liquid chromatography , liquid chromatography–mass spectrometry , contrast (vision) , analytical chemistry (journal) , artificial intelligence , biochemistry , extracellular , computer science
An automated high‐performance liquid chromatography (HPLC)/mass spectrometry instrument coupled on‐line with a microdialysis probe is described for the analysis of contrast agents in biological fluids. This system is used for pharmacokinetic and structure elucidation studies of contrast agents used in X‐ray and magnetic resonance imaging investigations. Additionally an LC/MS system for the direct analysis of urine, that obviates the need for conventional sample clean‐up, is described.