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Direct analysis of samples on paper by fast‐atom bombardment mass spectrometry
Author(s) -
Zhongping Yao,
Hanhui Wen,
Qinming Zha,
Weide He,
Shankai Zhao
Publication year - 1994
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290080611
Subject(s) - chemistry , dodecylbenzene , mass spectrometry , fast atom bombardment , mass spectrum , chromatography , analytical chemistry (journal) , detection limit , sulfonate , sodium , organic chemistry
Abstract A method for obtaining fast‐atom bombardment mass spectra of samples on paper is described in which a scrap trimmed from the paper of interest is adhered to the FAB probe tip with a strip of double‐faced adhesive tape. After addition of suitable matrix (e.g. glycerol or thioglycerol) to the scrap, the probe is introduced into the mass spectrometer to obtain mass spectra in the usual manner. The method is demonstrated by analysing some paper containing hexadecyltrimethylammonium bromide, sodium dodecylbenzene sulfonate and vanillic acid. The method is also used to characterize paper chromatographic spots, by which the fractions of a mixture of three amino acids (L‐glutamic acid, L‐proline and L‐valine) separated by paper chromatography are easily determined. The detection limit of the method is well below 10 ng with respect to hexadecyltrimethylammonium bromide.