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Study of anticancer drug interaction with DNA by means of particle‐induced desorption mass spectrometry: Prospydine and deoxyguanosine‐5′‐monophosphate
Author(s) -
Sukhodub Leonid F.,
Grebenik Lujdmila I.,
Chivanov Vadim D.
Publication year - 1994
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290080214
Subject(s) - chemistry , deoxyguanosine , adduct , desorption , mass spectrometry , drug , dna , particle (ecology) , chromatography , biochemistry , organic chemistry , pharmacology , adsorption , medicine , oceanography , geology
Using 252 CF particle desorption mass spectrometry, the interaction between an antitumour drug prospydine (Pro) and deoxyguanosine‐5′‐monophosphate (pdG) has been studied. The adduct which corresponds to a peak at m/z 524.5 and which occurs as a result of the particular degradation of Pro during its alkalating of pdG has been found.