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Capillary column supercritical fluid chromatography/mass spectrometry of polycyclic aromatic compounds using atmospheric pressure chemical ionization
Author(s) -
Thomas Darren,
Greig Sim P.,
Benoit Frank M.
Publication year - 1994
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290080120
Subject(s) - chemistry , chromatography , mass spectrometry , atmospheric pressure chemical ionization , supercritical fluid chromatography , chemical ionization , analytical chemistry (journal) , gas chromatography , ionization , ion , organic chemistry
Capillary column supercritical fluid chromatography (SCF) was combined with atmospheric pressure chemical ionization (APCI) mass spectrometry through a heated pneumatic‐nebulizer interface, originally developed for liquid chromatography/mass spectrometry (LC/MS), and subsequently modified for use with supercritical fluid chromatography/mass spectrometry (SFC/MS). A high pressure syringe pump was used to pass SFC‐grade carbon dioxide, used as the mobile phase, through a capillary SFC column which was contained in an oven, maintained at 100°C. The eluent passed through the heated pneumatic‐nebulizer interface into the ionization region of the mass spectrometer with the aid of the flow of nebulizing gas. The system was optimized using benz[ a ]anthracene, and then applied to analyze a standard mixture of polycyclic aromatic compounds (PACs) as well as complex mixtures of PACs obtained by the fractionation of a pond sediment contaminated by coke‐oven residues. A detection limit of 40 pg was established for chrysene.