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Small volume and low flow‐rate electrospray lonization mass spectrometry of aqueous samples
Author(s) -
Gale David C.,
Smith Richard D.
Publication year - 1993
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290071111
Subject(s) - chemistry , electrospray ionization , electrospray , extractive electrospray ionization , volumetric flow rate , analytical chemistry (journal) , mass spectrometry , aqueous solution , chromatography , capillary action , ionization , volume (thermodynamics) , common emitter , ion source , sample preparation in mass spectrometry , ion , optoelectronics , mechanics , organic chemistry , physics , materials science , quantum mechanics , composite material
A new electrospray ionization source (emitter) has been developed which allows the effective utilization of very small sample volumes at much lower flow rates than previously demonstrated. A small diameter etcched‐tip capillary has been incorporated into a pressure‐infusion electrospray ionization source. The ability to electro‐spray aqueous solutions without the use of an ancillary sheath flow is demonstrated with several biopolymers. High signal intensities and stable signals are observed for this source in a comparison with a standard methanol‐sheath source.