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Optimization of a commercial liquid chromatography/mass spectrometry interface by statistical experimental design
Author(s) -
Huang S. K.,
Glancy S. B.,
Stansbury W. F.
Publication year - 1993
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290070808
Subject(s) - chemistry , chromatography , mass spectrometry , response surface methodology , analytical chemistry (journal) , central composite design , ion source , particle beam , high performance liquid chromatography , ion , beam (structure) , organic chemistry , physics , optics
The efficiency of delivering 4‐methoxy phenyl acetic acid particle beam emerging from a commercial liquid chromatography/mass spectrometry interface into the ion source of the mass spectrometer was optimized using response surface modeling (RSM) of the statistical experimental design. It was found that the temperature and pressure of the nebulizer, and the temperature of the desolvation chamber are the major factors for the optimization.