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A comparison of the fragmentation patterns of 5‐fluoromethyl‐3,4‐disubstituted isoxazoles and 5‐methyl analogs
Author(s) -
Favretto Donata,
Traldi Pietro,
Bravo Pierfrancesco,
Diliddo Dario,
Resnati Giuseppe
Publication year - 1993
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290070723
Subject(s) - chemistry , fragmentation (computing) , metastability , fluorine , ion , electron ionization , computational chemistry , medicinal chemistry , organic chemistry , computer science , operating system , ionization
The influence of fluorine substitution on the fragmentation processes of some substituted isoxazoles has been studied by comparing the electron‐impact‐induced mass spectrometric behaviour of some 5‐monofluoromethyl‐3,4‐disubstituted isoxazoles with that of the corresponding 5‐methyl analogs. Some interesting and unusual cleavages have been detected and a rationale has been developed for them on the basis of metastable ion studies and accurate mass measurements. Evidence has been found of the influence of fluorine in the stabilization of molecular and fragment ions.