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Fast‐atom bombardment/mass‐analysed ion kinetic energy spectrometry of inositol phosphates
Author(s) -
Walton Terence J.,
Hughes Soraya Y.
Publication year - 1993
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290070631
Subject(s) - chemistry , fast atom bombardment , mass spectrometry , inositol , ion , phosphate , kinetic energy , dissociation (chemistry) , mass spectrum , vicinal , collision induced dissociation , analytical chemistry (journal) , chromatography , organic chemistry , tandem mass spectrometry , biochemistry , physics , receptor , quantum mechanics
The application of fast‐atom bombardment mass Spectrometry and collisiorutlly induced dissociation with mass‐analysed ion kinetic energy (CID/MIKE) Spectrometry of representative inositol mono‐, bis‐ and trisphos‐phates is described. Based on their CID/MIKE spectra, inositol polyphosphates containing vicinal phosphate groups could be distinguished from isomers in which adjacent phosphate groups were absent. The potential value of this procedure in studies of the biochemistry of intracellular second messengers is discussed.