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Contributions of fast‐atom bombardment mass spectrometry to studies of cyclic nucleotide biochemistry
Author(s) -
Newton Russell P.
Publication year - 1993
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290070626
Subject(s) - chemistry , fast atom bombardment , mass spectrometry , nucleotide , cyclic nucleotide , kinetic energy , mass spectrum , ion , endogeny , enzyme , chromatography , biochemistry , organic chemistry , physics , quantum mechanics , gene
Cyclic nucleotides are biochemical second messengers which mediate the actions of many hormones and neurotransmitters. Fast‐atom bombardment (FAB) mass spectrometry and mass‐analysed ion kinetic energy (MIKE) spectra have provided a means of unambiguous identification of these compounds, and in addition to identifying endogenous putative cyclic nueleotides and their synthetic analogues FAB/MIKE analysis has now been applied to good effect to both qualitative and quantitative studies of cyclic nuclcotide‐related enzymes. Here the application of this mass spectrometric technique to cyclic nucleotides is described and its impact upon this field reviewed.